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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342656
Species: Homo sapiens
RGD Object: Gene
Symbol: KLF4
Name: KLF transcription factor 4
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLF4decreases expressionEXP 6480464CTDbisphenol S results in decreased expression of KLF4 mRNAPMID:37834465
KLF4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with perfluorooctanoic acid co-treated with bisphenol S co-treated with perfluorooctane sulfonic acid] results in increased expression of KLF4 mRNA; [bisphenol S co-treated with perfluorooctane sulfonic acid] results in increased expression of KLF4 mRNA; [bisphenol S co-treated with perfluorooctanoic acid] results in increased expression of KLF4 mRNAPMID:37834465
KLF4increases expressionISOKlf4 (Mus musculus)6480464CTDbisphenol S results in increased expression of KLF4 mRNAPMID:30951980
KLF4increases methylationISOKlf4 (Mus musculus)6480464CTDbisphenol S results in increased methylation of KLF4 exonPMID:33297965
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