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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:3435
Term: carrageenan
Definition: A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, 'carrageen moss' (Irish moss).
Chemical ID: MESH:D002351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTDCarrageenan results in increased expression of NOS2 proteinPMID:26418808
Nos2multiple interactionsEXP 6480464CTDfucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]; Indomethacin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]PMID:26418808
Nos2increases activityISONos2 (Rattus norvegicus)6480464CTDCarrageenan results in increased activity of NOS2 proteinPMID:9890637
Nos2increases expressionISONos2 (Rattus norvegicus)6480464CTDCarrageenan results in increased expression of NOS2 mRNA; Carrageenan results in increased expression of NOS2 proteinPMID:15860553 PMID:18429935 PMID:27803785 PMID:7542281
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDadelmidrol inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]; Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NOS2 protein]; Carrageenan promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]; Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]PMID:15860553 PMID:18429935 PMID:22330755 PMID:27803785 PMID:7542281
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