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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases acetylationISOAkt1 (Rattus norvegicus)6480464CTDMethylcholanthrene results in decreased acetylation of AKT1 promoterPMID:29094188
AKT1increases expressionISOAkt1 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of AKT1 mRNAPMID:29094188
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]PMID:29094188
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