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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDMethylcholanthrene results in increased expression of CDKN1A mRNAPMID:15882963
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDMethylcholanthrene results in increased expression of CDKN1A proteinPMID:18022818
Cdkn1aincreases response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A protein results in increased susceptibility to MethylcholanthrenePMID:18022818
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTDSB 203580 inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A mRNA]PMID:15882963
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]; resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]PMID:18022818
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