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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta2
Name: glutathione S-transferase alpha 2
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta2decreases expressionEXP 6480464CTDMethylcholanthrene results in decreased expression of GSTA2 mRNAPMID:10476907
Gsta2increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of GSTA2 mRNAPMID:11328961 PMID:23273579
Gsta2increases expressionISOGsta2 (Mus musculus)6480464CTDMethylcholanthrene results in increased expression of GSTA2 mRNAPMID:15297030
Gsta2multiple interactionsISOGsta2 (Mus musculus)6480464CTD[Methylcholanthrene co-treated with Copper] results in increased activity of GSTA2 protein; Copper inhibits the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of GSTA2 mRNA]PMID:15297030
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