A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID:
MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
3,4,5,3',4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]; [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [6,2',4'-trimethoxyflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM protein]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein modified form]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VIM mRNA]; AHR protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; Oxygen deficiency affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]
AHR gene mutant form affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl; AHR protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR protein
3,4,5,3',4'-pentachlorobiphenyl binds to and affects the localization of AHR protein; 3,4,5,3',4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [aroclor 1260 results in decreased expression of AHR mRNA]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [2,3,7,8-tetrachlorodibenzofuran co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased activity of AHR protein; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC2 mRNA; [3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA; [3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC5 mRNA; [3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC6 mRNA; [3,4,5,3',4'-pentachlorobiphenyl binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] results in increased expression of AHR mRNA; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]; aroclor 1260 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AHR mRNA]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein]; 3,4,5,3',4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [AHR gene mutant form affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased expression of CCL11 mRNA; [AHR gene mutant form affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased expression of CCL22 mRNA; [AHR gene mutant form affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased expression of IL11 mRNA; [AHR gene mutant form affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in increased secretion of LHB protein; AHR affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PCK1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GGT1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GPX1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ADH1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ADH4 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALAD mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALDH1A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALOX15 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALOX5 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AOC1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ARNT mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CES2C mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CHST1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP19A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A2 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP27B1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B3 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2C13 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2C6V1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2C7 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2E1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP3A23-3A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FBP1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GCKR mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GPX2 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GPX5 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTM3 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTP1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HK2 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B2 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B3 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LPO mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MARCKS mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MPO mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MTHFR mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NOS2 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKLR mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SRD5A1 mRNA]; AHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of XDH mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ACOX1 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CREM mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of G6PC1 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMGCS2 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGF1 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PC mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PCK1 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PYGL mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC2A2 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PPARA mRNA]; AHR protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Selenic Acid deficiency inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA]; Selenic Acid inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA]
