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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7309016480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl affects the expression of HMOX1 mRNA

PMID:21703328
increases expressionISORGD:107176480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl results in increased expression of HMOX1 protein

PMID:28163111
increases expressionISORGD:7309016480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl results in increased expression of HMOX1 mRNA

PMID:30768972
multiple interactionsISORGD:107176480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with 3, 4, 5, 3', 4'-pentachlorobiphenyl] results in increased expression of HMOX1 mRNA

PMID:28163111
multiple interactionsISORGD:7309016480464CTD[Lipopolysaccharides co-treated with IFNG protein] promotes the reaction [3, 4, 5, 3', 4'-pentachlorobiphenyl results in increased expression of HMOX1 mRNA]

PMID:30768972
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.