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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfdecreases expressionISOEgf (Rattus norvegicus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EGF mRNAPMID:20959002
Egfmultiple interactionsISOEGF (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [EGF protein binds to EGFR protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]PMID:29329451
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