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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: CHEBI:34310
Term: (24S)-24-hydroxycholesterol
Definition: A 24-hydroxycholesterol that has S configuration at position 24.
Chemical ID: MESH:C044563
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1affects abundanceISORGD:13153146480464CTDCYP46A1 gene SNP affects the abundance of 24-hydroxycholesterol

PMID:19286353
Cyp46a1increases chemical synthesisISORGD:13153146480464CTDCYP46A1 protein results in increased chemical synthesis of 24-hydroxycholesterol

PMID:14640697
Cyp46a1increases metabolic processingISORGD:13153146480464CTDCYP46A1 protein results in increased metabolism of 24-hydroxycholesterol

PMID:14640697
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.