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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:3429
Term: Carnosol
Definition: A diterpenoid that has formula C20H26O4.
Chemical ID: MESH:C068623
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases glutathionylationISORELA (Homo sapiens)6480464CTDcarnosol results in increased glutathionylation of RELA proteinPMID:20116392
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]PMID:20116392
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