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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:34247
Term: 2,6-di-tert-butyl-4-methylphenol
Definition: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Chemical ID: MESH:D002084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:25036480464CTDButylated Hydroxytoluene results in increased activity of NQO1 protein

PMID:16045903
increases expressionISORGD:25036480464CTDButylated Hydroxytoluene results in increased expression of NQO1 mRNA

PMID:20308224
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.