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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732222
Species: Mus musculus
RGD Object: Gene
Symbol: Gsr
Name: glutathione reductase
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDCarmustine results in decreased activity of GSR proteinPMID:15857610 PMID:17498860
Gsrmultiple interactionsEXP 6480464CTD[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Carmustine results in decreased activity of GSR protein] which results in decreased susceptibility to chromium hexavalent ion; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR proteinPMID:12114195 PMID:12477282 PMID:17498860
Gsrdecreases activityISOGsr (Rattus norvegicus)6480464CTDCarmustine results in decreased activity of GSR proteinPMID:12433058 PMID:15104113 PMID:17382203 PMID:18528683 PMID:20046642 PMID:2116959 PMID:21600974
Gsrdecreases activityISOGSR (Homo sapiens)6480464CTDCarmustine results in decreased activity of GSR proteinPMID:12632252 PMID:15857610 PMID:18155673 PMID:19401447 PMID:19668867 PMID:19856331
Gsrmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Carmustine results in decreased activity of GSR protein] which results in increased uptake of Calcium; MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; Zinc Sulfate inhibits the reaction [Carmustine results in decreased activity of GSR protein]PMID:12967637 PMID:15321730 PMID:15720826 PMID:16288907 PMID:18528683 PMID:20046642
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTD[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Doxorubicin; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride; Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]; NADP affects the reaction [Carmustine results in decreased activity of GSR protein]PMID:12632252 PMID:16160061 PMID:19668867
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