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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 mRNA affects the susceptibility to CarmustinePMID:16365179
Sod2decreases activityISOSOD2 (Homo sapiens)6480464CTDCarmustine results in decreased activity of SOD2 proteinPMID:19856331
Sod2increases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in increased susceptibility to CarmustinePMID:8877099
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDPyruvates inhibits the reaction [SOD2 protein results in increased susceptibility to Carmustine]PMID:8877099
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