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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtdecreases expressionEXP 6480464CTDCarmustine results in decreased expression of MGMT proteinPMID:15104113
Mgmtaffects response to substanceISOMgmt (Mus musculus)6480464CTDMGMT protein affects the susceptibility to CarmustinePMID:19844954
Mgmtaffects response to substanceISOMGMT (Homo sapiens)6480464CTDMGMT gene modified form affects the susceptibility to Carmustine; MGMT promoter modified form affects the susceptibility to Carmustine; MGMT protein affects the susceptibility to CarmustinePMID:12394182 PMID:12684420 PMID:16033832 PMID:18430789 PMID:19637364
Mgmtdecreases activityISOMgmt (Mus musculus)6480464CTDCarmustine results in decreased activity of MGMT proteinPMID:16126841
Mgmtdecreases response to substanceISOMgmt (Mus musculus)6480464CTDMGMT protein results in decreased susceptibility to CarmustinePMID:15284838
Mgmtdecreases response to substanceISOMGMT (Homo sapiens)6480464CTDMGMT mRNA results in decreased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine analog; MGMT results in decreased susceptibility to CarmustinePMID:12479369 PMID:14742745 PMID:15814657 PMID:15833865 PMID:16039682 PMID:16365179 PMID:16405512 PMID:16899598 PMID:18492797 PMID:20450874 PMID:20556481 PMID:20654586 PMID:9918549
Mgmtincreases alkylationISOMGMT (Homo sapiens)6480464CTDCarmustine results in increased alkylation of MGMT proteinPMID:8823159
Mgmtincreases response to substanceISOMGMT (Homo sapiens)6480464CTDMGMT mutant form results in increased susceptibility to CarmustinePMID:26208482
Mgmtmultiple interactionsISOMgmt (Mus musculus)6480464CTD[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]PMID:14707273 PMID:19415780 PMID:19844954
Mgmtmultiple interactionsISOMGMT (Homo sapiens)6480464CTD[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine; [MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; [O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; O(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]PMID:11792417 PMID:11945064 PMID:12036916 PMID:12394182 PMID:12479369 PMID:12950064 PMID:14506174 PMID:14617757 PMID:14670122 PMID:14707273 PMID:15319033 PMID:16278409 PMID:16432170 PMID:16927363 PMID:17597106 PMID:19415780 PMID:20450874
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