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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2650
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Acc ID: CHEBI:34204
Term: 2,2',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.
Chemical ID: MESH:C035976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabrb2multiple interactionsISORGD:7353556480464CTD2 4 2' 4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] 2 4 2' 4'-tetrachlorobiphenyl promotes the reaction [3 5-dibromo-2-2 4-dibromophenoxyphenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] 2 4 2' 4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] 2 4 2' 4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] 2 4 4'-trichlorobiphenyl inhibits the reaction [2 4 2' 4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] 2 4 5 2' 4' 5'-hexachlorobiphenyl inhibits the reaction [2 4 2' 4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] 3 5-dibromo-2-2 4-dibromophenoxyphenol promotes the reaction [2 4 2' 4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] [2 4 2' 4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] [3 5-dibromo-2-2 4-dibromophenoxyphenol co-treated with 2 4 2' 4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] PCB 180 inhibits the reaction [2 4 2' 4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

PMID:20819908 PMID:20861069
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