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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69473
Species: Homo sapiens
RGD Object: Gene
Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF1decreases expressionISOSrebf1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF1 mRNAPMID:20005886 PMID:21851831
SREBF1multiple interactionsISOSrebf1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA]; [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of SREBF1 mRNA; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF1 mRNA]PMID:21851831 PMID:23756648 PMID:30722647
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