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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345409
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGA1
Name: high mobility group AT-hook 1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGA1increases activityEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of HMGA1 proteinPMID:27589886
HMGA1multiple interactionsISOHmga1 (Mus musculus)6480464CTD[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HMGA1 mRNAPMID:25510870
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