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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfraffects bindingISOEGFR (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl binds to EGFR proteinPMID:29329451
Egfraffects localizationISOEGFR (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl affects the localization of EGFR proteinPMID:19632255
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of EGFR proteinPMID:19632255
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [EGF protein binds to EGFR protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]PMID:29329451
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