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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350859
Species: Homo sapiens
RGD Object: Gene
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:34107
Term: 1-nitropyrene
Definition: A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.
Chemical ID: MESH:C032668
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRASincreases mutagenesisISOKras (Mus musculus)6480464CTD1-nitropyrene results in increased mutagenesis of KRAS genePMID:10396879 PMID:11746253 PMID:9726818
KRASmultiple interactionsISOKras (Mus musculus)6480464CTD[1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS genePMID:10396879 PMID:11746253 PMID:12616606
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