GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | increases expression | EXP | | 6480464 | CTD | 1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein | PMID:12117779 PMID:17240030 PMID:19961161 | Cyp1a1 | increases stability | EXP | | 6480464 | CTD | 1-nitropyrene results in increased stability of CYP1A1 mRNA | PMID:19961161 | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] | PMID:19961161 | Cyp1a1 | increases degradation | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | 1-nitropyrene results in increased degradation of CYP1A1 protein | PMID:16280210 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Rattus norvegicus) | 6480464 | CTD | 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] | PMID:18493746 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] | PMID:16280210 PMID:18493746 PMID:22044530 | |
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