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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:34027
Term: 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Definition: A diarylmethane that has formula C14H9Cl5.
Chemical ID: MESH:C016340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases activityEXP 6480464CTDo,p'-DDT results in increased activity of ESR2 proteinPMID:9860891
Esr2multiple interactionsEXP 6480464CTD[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 proteinPMID:9860891
Esr2decreases expressionISOEsr2 (Mus musculus)6480464CTDo,p'-DDT results in decreased expression of ESR2 mRNA; o,p'-DDT results in decreased expression of ESR2 proteinPMID:28263910
Esr2decreases expressionISOESR2 (Homo sapiens)6480464CTDo,p'-DDT results in decreased expression of ESR2 mRNAPMID:18700809
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDo,p'-DDT results in increased activity of ESR2 proteinPMID:15064155 PMID:26812056
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDo,p'-DDT binds to and results in increased activity of ESR2 proteinPMID:16626760 PMID:9751507
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