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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:34025
Term: 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Definition: A bisphenol that has formula C14H11Cl3O2.
Chemical ID: MESH:C404910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRincreases expressionEXP 6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PGR mRNAPMID:23384675
PGRmultiple interactionsEXP 6480464CTDESR1 protein inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PGR mRNA]PMID:23384675
PGRdecreases expressionISOPgr (Mus musculus)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of PGR mRNAPMID:11509743
PGRincreases expressionISOPgr (Rattus norvegicus)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PGR mRNAPMID:10774817
PGRmultiple interactionsISOPgr (Mus musculus)6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of PGR mRNA; [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of PGR mRNAPMID:11509743
PGRmultiple interactionsISOPgr (Rattus norvegicus)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PGR mRNA]PMID:19414516
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