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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: CHEBI:34025
Term: 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Definition: A bisphenol that has formula C14H11Cl3O2.
Chemical ID: MESH:C404910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1Rmultiple interactionsISOIgf1r (Mus musculus)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased phosphorylation of and results in increased activity of IGF1R protein; ESR1 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased phosphorylation of and results in increased activity of IGF1R protein]PMID:10965916
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