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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:3392
Term: carbendazim
Definition: A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.
Chemical ID: MESH:C006698
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDcarbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 proteinPMID:27286660
Cyp1a1multiple interactionsEXP 6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]PMID:27286660
Cyp1a1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDcarbendazim results in increased expression of CYP1A1 proteinPMID:10103034
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDcarbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 proteinPMID:21784029 PMID:27286660 PMID:32194361
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