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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2557
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ephx1
Name: epoxide hydrolase 1
Acc ID: CHEBI:3388
Term: carbamazepine-10,11-epoxide
Definition: An epoxide and metabolite of carbamazepine.
Chemical ID: MESH:C012227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx1multiple interactionsISOEPHX1 (Homo sapiens)6480464CTD[EPHX1 gene SNP affects the metabolism of carbamazepine epoxide] which affects the chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; [EPHX1 protein results in increased metabolism of carbamazepine epoxide] which results in increased chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamidePMID:15692831
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