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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736260
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:3387
Term: carbamazepine
Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Chemical ID: MESH:D002220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3affects expressionISOEIF2AK3 (Homo sapiens)6480464CTDCarbamazepine affects the expression of EIF2AK3 mRNAPMID:24752500
Eif2ak3increases activityISOEIF2AK3 (Homo sapiens)6480464CTDCarbamazepine results in increased activity of EIF2AK3 proteinPMID:24752500
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