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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDCapsaicin affects the expression of BAX proteinPMID:34939720
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDCapsaicin affects the localization of BAX proteinPMID:19331147
Baxincreases activityISOBax (Mus musculus)6480464CTDCapsaicin results in increased activity of BAX proteinPMID:17295509
Baxincreases expressionISOBax (Mus musculus)6480464CTDCapsaicin results in increased expression of BAXPMID:20069556
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCapsaicin results in increased expression of BAX; Capsaicin results in increased expression of BAX mRNA; Capsaicin results in increased expression of BAX proteinPMID:16540674 PMID:17292493 PMID:19002586
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDTP53 protein promotes the reaction [Capsaicin results in increased expression of BAX protein]; TRPV6 protein promotes the reaction [Capsaicin results in increased expression of BAX protein]PMID:17292493
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