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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6increases expressionEXP 6480464CTDCapsaicin results in increased expression of IL6 mRNA; Capsaicin results in increased expression of IL6 proteinPMID:16173059 PMID:17306835 PMID:17560936 PMID:21474332
IL6increases secretionEXP 6480464CTDCapsaicin results in increased secretion of IL6 proteinPMID:20619260 PMID:21474332 PMID:22171160
IL6multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 7-oxozeanol inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; bisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Capsaicin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; DUSP1 mutant form promotes the reaction [Capsaicin results in increased secretion of IL6 protein]; Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; MAPK8 mutant form inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; NFKB1 mutant form inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; RTKI cpd affects the reaction [Capsaicin results in increased secretion of IL6 protein]; Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 mRNA]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 protein]PMID:16173059 PMID:17306835 PMID:17505005 PMID:17560936 PMID:20619260 PMID:21474332 PMID:22171160 PMID:30244119
IL6decreases expressionISOIl6 (Mus musculus)6480464CTDCapsaicin results in decreased expression of IL6 mRNA; Capsaicin results in decreased expression of IL6 proteinPMID:17719033 PMID:19798065
IL6decreases expressionISOIl6 (Rattus norvegicus)6480464CTDCapsaicin results in decreased expression of IL6 proteinPMID:15502055
IL6decreases secretionISOIl6 (Mus musculus)6480464CTDCapsaicin results in decreased secretion of IL6 proteinPMID:17719033 PMID:19798065
IL6increases expressionISOIl6 (Rattus norvegicus)6480464CTDCapsaicin results in increased expression of IL6 proteinPMID:15265675 PMID:22150557
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDcapsazepine inhibits the reaction [Capsaicin results in decreased secretion of IL6 protein]; troglitazone promotes the reaction [Capsaicin results in decreased secretion of IL6 protein]PMID:17719033 PMID:19798065
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [IL6 protein results in increased expression of GFAP mRNA]; Capsaicin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Ketotifen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; spantide II inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein]PMID:15265675 PMID:19285962 PMID:22150557 PMID:36925032
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