GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL6 | increases expression | EXP | | 6480464 | CTD | Capsaicin results in increased expression of IL6 mRNA; Capsaicin results in increased expression of IL6 protein | PMID:16173059 PMID:17306835 PMID:17560936 PMID:21474332 | IL6 | increases secretion | EXP | | 6480464 | CTD | Capsaicin results in increased secretion of IL6 protein | PMID:20619260 PMID:21474332 PMID:22171160 | IL6 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 7-oxozeanol inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; bisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Capsaicin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; DUSP1 mutant form promotes the reaction [Capsaicin results in increased secretion of IL6 protein]; Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; MAPK8 mutant form inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; NFKB1 mutant form inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]; RTKI cpd affects the reaction [Capsaicin results in increased secretion of IL6 protein]; Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 mRNA]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 protein] | PMID:16173059 PMID:17306835 PMID:17505005 PMID:17560936 PMID:20619260 PMID:21474332 PMID:22171160 PMID:30244119 | IL6 | decreases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Capsaicin results in decreased expression of IL6 mRNA; Capsaicin results in decreased expression of IL6 protein | PMID:17719033 PMID:19798065 | IL6 | decreases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Capsaicin results in decreased expression of IL6 protein | PMID:15502055 | IL6 | decreases secretion | ISO | Il6 (Mus musculus) | 6480464 | CTD | Capsaicin results in decreased secretion of IL6 protein | PMID:17719033 PMID:19798065 | IL6 | increases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Capsaicin results in increased expression of IL6 protein | PMID:15265675 PMID:22150557 | IL6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | capsazepine inhibits the reaction [Capsaicin results in decreased secretion of IL6 protein]; troglitazone promotes the reaction [Capsaicin results in decreased secretion of IL6 protein] | PMID:17719033 PMID:19798065 | IL6 | multiple interactions | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein]; Capsaicin inhibits the reaction [IL6 protein results in increased expression of GFAP mRNA]; Capsaicin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Ketotifen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; spantide II inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein] | PMID:15265675 PMID:19285962 PMID:22150557 PMID:36925032 | |
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