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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11406
Species: Mus musculus
RGD Object: Gene
Symbol: Trf
Name: transferrin
Acc ID: CHEBI:33629
Term: aluminium(0)
Definition: An elemental aluminium that has formula Al.
Chemical ID: MESH:D000535
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trfaffects bindingEXP 6480464CTDTRF protein binds to AluminumPMID:15149824
Trfaffects bindingISOTF (Homo sapiens)6480464CTDAluminum binds to TF protein; TF protein binds to AluminumPMID:11193083 PMID:12627980 PMID:19859668 PMID:2039817 PMID:22873711 PMID:2308257 PMID:8782865
Trfincreases uptakeISOTF (Homo sapiens)6480464CTDTF protein results in increased uptake of AluminumPMID:1375080
Trfmultiple interactionsISOTF (Homo sapiens)6480464CTD[Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of AluminumPMID:10978387 PMID:11193083 PMID:2039817 PMID:2308257 PMID:8782865
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