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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69170
Species: Homo sapiens
RGD Object: Gene
Symbol: UCP2
Name: uncoupling protein 2
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UCP2decreases expressionISOUcp2 (Rattus norvegicus)6480464CTDcandesartan results in decreased expression of UCP2 mRNAPMID:16685210
UCP2multiple interactionsISOUcp2 (Mus musculus)6480464CTDcandesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]PMID:20667613
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