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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68977
Species: Homo sapiens
RGD Object: Gene
Symbol: AGTR1
Name: angiotensin II receptor type 1
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTR1multiple interactionsEXP 6480464CTDcandesartan binds to and results in decreased activity of AGTR1 proteinPMID:21474964
AGTR1decreases expressionISOAgtr1a (Rattus norvegicus)6480464CTDcandesartan results in decreased expression of AGTR1A mRNAPMID:18796534
AGTR1multiple interactionsISOAgtr1a (Rattus norvegicus)6480464CTDcandesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]PMID:15728788
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