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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615151
Species: Mus musculus
RGD Object: Gene
Symbol: Cd40lg
Name: CD40 ligand
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd40lgdecreases expressionISOCD40LG (Homo sapiens)6480464CTDcandesartan results in decreased expression of CD40LG proteinPMID:16443859
Cd40lgmultiple interactionsISOCD40LG (Homo sapiens)6480464CTDcandesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]PMID:16443859
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