Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731002
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CASP3
Name:	caspase 3

Acc ID:	CHEBI:33234
Term:	vitamin E
Definition:	Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID:	MESH:D024502

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CASP3	multiple interactions	EXP		6480464	CTD	Vitamin E inhibits the reaction [bioallethrin results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [cinnamaldehyde results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in increased activity of CASP3 protein]	PMID:15566391 PMID:16054126 PMID:28237877 PMID:30935902 PMID:35511042
CASP3	increases expression	ISO	Casp3 (Rattus norvegicus)	6480464	CTD	Vitamin E results in increased expression of CASP3 mRNA	PMID:32810592
CASP3	multiple interactions	ISO	Casp3 (Mus musculus)	6480464	CTD	Vitamin E inhibits the reaction [titanium dioxide results in increased activity of CASP3 protein]	PMID:30626778
CASP3	multiple interactions	ISO	Casp3 (Rattus norvegicus)	6480464	CTD	[Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [APP protein results in increased activity of CASP3]; Vitamin E inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; Vitamin E inhibits the reaction [Doxorubicin results in decreased expression of CASP3 mRNA]; Vitamin E inhibits the reaction [Nanotubes, Carbon results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]	PMID:12117551 PMID:16973328 PMID:21628957 PMID:21873648 PMID:22020378 PMID:23523949 PMID:27353299 PMID:31618080 PMID:32810592

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