Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737448
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Cat
Name:	catalase

Acc ID:	CHEBI:33217
Term:	3,3',5,5'-tetrabromobisphenol A
Definition:	A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID:	MESH:C020806

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cat	decreases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	tetrabromobisphenol A results in decreased activity of CAT protein	PMID:27718046
Cat	increases expression	ISO	CAT (Homo sapiens)	6480464	CTD	tetrabromobisphenol A results in increased expression of CAT mRNA	PMID:30951941
Cat	multiple interactions	ISO	Cat (Rattus norvegicus)	6480464	CTD	[bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; [tetrabromobisphenol A co-treated with Cadmium Chloride] results in increased activity of CAT protein; Butylated Hydroxyanisole inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]	PMID:27718046 PMID:29702088
Cat	multiple interactions	ISO	CAT (Homo sapiens)	6480464	CTD	Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of CAT mRNA]	PMID:30951941

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