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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:693256480464CTDtetrabromobisphenol A results in decreased expression of CYP11A1 mRNA

PMID:26988606, PMID:28300664
increases expressionISORGD:7356326480464CTDtetrabromobisphenol A results in increased expression of CYP11A1 mRNA

PMID:24014645
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.