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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734423
Species: Homo sapiens
RGD Object: Gene
Symbol: THRB
Name: thyroid hormone receptor beta
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THRBaffects bindingEXP 6480464CTDtetrabromobisphenol A analog binds to THRB protein; tetrabromobisphenol A binds to THRB proteinPMID:26718265 PMID:29763311 PMID:33095664
THRBmultiple interactionsEXP 6480464CTDtetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]PMID:15680168 PMID:19457453 PMID:19672399 PMID:29409039 PMID:29763311 PMID:31077750
THRBaffects expressionISOThrb (Rattus norvegicus)6480464CTDtetrabromobisphenol A affects the expression of THRB mRNAPMID:26988606
THRBincreases activityISOThrb (Rattus norvegicus)6480464CTDtetrabromobisphenol A results in increased activity of THRB proteinPMID:22015988
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