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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631377
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp7
Name: Sp7 transcription factor
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp7decreases expressionISOSp7 (Mus musculus)6480464CTDtetrabromobisphenol A results in decreased expression of SP7 mRNAPMID:25777084
Sp7multiple interactionsISOSp7 (Mus musculus)6480464CTDtetrabromobisphenol A inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]PMID:32473317
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