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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628595
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tubb3
Name: tubulin, beta 3 class III
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tubb3decreases expressionISOTubb3 (Mus musculus)6480464CTDtetrabromobisphenol A results in decreased expression of TUBB3 mRNAPMID:25172293
Tubb3increases expressionISOTUBB3 (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased expression of TUBB3 proteinPMID:31675489
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