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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDtetrabromobisphenol A results in increased expression of IL1B proteinPMID:28301301
Il1bincreases secretionEXP 6480464CTDtetrabromobisphenol A results in increased secretion of IL1B proteinPMID:31332466
Il1baffects secretionISOIL1B (Homo sapiens)6480464CTDtetrabromobisphenol A affects the secretion of IL1B proteinPMID:27297965
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDtetrabromobisphenol A results in increased expression of IL1B mRNAPMID:20077215
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDtetrabromobisphenol A results in increased secretion of IL1B proteinPMID:20077215
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDtetrabromobisphenol A inhibits the reaction [Antigens, Bacterial results in increased expression of IL1B protein]PMID:30055667
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