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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737483
Species: Mus musculus
RGD Object: Gene
Symbol: Itgb3
Name: integrin beta 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgb3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ITGB3 proteinPMID:26884915
Itgb3increases expressionEXP 6480464CTDbisphenol A results in increased expression of ITGB3 mRNAPMID:30951980
Itgb3decreases expressionISOITGB3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ITGB3 mRNAPMID:29275510
Itgb3decreases expressionISOItgb3 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of ITGB3 mRNAPMID:21285323 PMID:25181051 PMID:32145629
Itgb3increases expressionISOITGB3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of ITGB3 mRNAPMID:27685785
Itgb3increases expressionISOItgb3 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of ITGB3 mRNAPMID:30816183 PMID:32528016
Itgb3increases methylationISOItgb3 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of ITGB3 genePMID:28505145
Itgb3multiple interactionsISOITGB3 (Homo sapiens)6480464CTDITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]PMID:22227104
Itgb3multiple interactionsISOItgb3 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of ITGB3 genePMID:28505145
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