Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTdecreases expressionEXP 6480464CTDbisphenol A analog results in decreased expression of COMT mRNA; bisphenol A results in decreased expression of COMT mRNA; bisphenol A results in decreased expression of COMT proteinPMID:24040167 PMID:24214726 PMID:31675489 PMID:32387340
COMTincreases expressionEXP 6480464CTDbisphenol A results in increased expression of COMT proteinPMID:34186270
COMTincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of COMT promoterPMID:24214726
COMTmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA]PMID:24040167
COMTaffects expressionISOComt (Rattus norvegicus)6480464CTDbisphenol A affects the expression of COMT mRNAPMID:30903817
COMTdecreases expressionISOComt (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of COMT mRNAPMID:26186136 PMID:32145629 PMID:34947998
COMTincreases expressionISOComt (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of COMT mRNAPMID:25181051 PMID:29552716
Go Back to source page   Continue to Ontology report