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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737021
Species: Homo sapiens
RGD Object: Gene
Symbol: TSHR
Name: thyroid stimulating hormone receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TSHRincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of TSHR genePMID:31601247
TSHRmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of TSHR gene; bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]PMID:19766106 PMID:31601247
TSHRaffects expressionISOTshr (Mus musculus)6480464CTDbisphenol A affects the expression of TSHR mRNAPMID:35341816
TSHRdecreases expressionISOTshr (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of TSHR mRNAPMID:25181051
TSHRincreases expressionISOTshr (Mus musculus)6480464CTDbisphenol A results in increased expression of TSHR mRNAPMID:32156529
TSHRincreases expressionISOTshr (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of TSHR mRNAPMID:23238275 PMID:30816183
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