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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736886
Species: Homo sapiens
RGD Object: Gene
Symbol: HPGD
Name: 15-hydroxyprostaglandin dehydrogenase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HPGDdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HPGD proteinPMID:31675489
HPGDaffects expressionISOHpgd (Mus musculus)6480464CTDbisphenol A affects the expression of HPGD mRNAPMID:27082013
HPGDdecreases expressionISOHpgd (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HPGD mRNAPMID:25181051 PMID:34947998
HPGDmultiple interactionsISOHpgd (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of HPGD mRNAPMID:26496021
HPGDmultiple interactionsISOHpgd (Mus musculus)6480464CTD[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]PMID:27082013
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