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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736675
Species: Homo sapiens
RGD Object: Gene
Symbol: SQLE
Name: squalene epoxidase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SQLEaffects expressionEXP 6480464CTDbisphenol A affects the expression of SQLE mRNAPMID:30903817
SQLEdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SQLE mRNA; bisphenol A results in decreased expression of SQLE proteinPMID:19371625 PMID:33376534
SQLEincreases expressionEXP 6480464CTDbisphenol A results in increased expression of SQLE mRNAPMID:25047013
SQLEdecreases expressionISOSqle (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of SQLE mRNAPMID:30816183 PMID:32528016 PMID:34947998
SQLEincreases expressionISOSqle (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of SQLE mRNAPMID:25181051 PMID:31771501 PMID:32145629 PMID:32339907
SQLEincreases expressionISOSqle (Mus musculus)6480464CTDbisphenol A results in increased expression of SQLE mRNAPMID:21932408 PMID:25168180 PMID:25270620 PMID:27502578
SQLEmultiple interactionsISOSqle (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of SQLE mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNAPMID:28433925 PMID:35739755
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