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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736507
Species: Mus musculus
RGD Object: Gene
Symbol: Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn8adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SCN8A mRNAPMID:32156529
Scn8adecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of SCN8A promoterPMID:27312807
Scn8adecreases expressionISOScn8a (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of SCN8A mRNAPMID:25181051 PMID:30816183
Scn8aincreases expressionISOScn8a (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of SCN8A mRNAPMID:29097150
Scn8aincreases methylationISOScn8a (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of SCN8A genePMID:28505145
Scn8amultiple interactionsISOSCN8A (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SCN8A mRNAPMID:28628672
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