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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736345
Species: Homo sapiens
RGD Object: Gene
Symbol: PCSK2
Name: proprotein convertase subtilisin/kexin type 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCSK2decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of PCSK2 genePMID:31601247
PCSK2decreases expressionISOPcsk2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of PCSK2 mRNAPMID:25181051 PMID:30816183
PCSK2decreases expressionISOPcsk2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of PCSK2 mRNAPMID:32156529
PCSK2increases expressionISOPcsk2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of PCSK2 mRNAPMID:34947998
PCSK2increases expressionISOPcsk2 (Mus musculus)6480464CTDbisphenol A results in increased expression of PCSK2 mRNAPMID:30149043
PCSK2increases methylationISOPcsk2 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of PCSK2 genePMID:28505145
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