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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of IL4 mRNAPMID:31714645
IL4decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of IL4 genePMID:31601247
IL4decreases secretionEXP 6480464CTDbisphenol A results in decreased secretion of IL4 proteinPMID:31714645
IL4increases expressionEXP 6480464CTDbisphenol A results in increased expression of IL4 mRNAPMID:19415476
IL4multiple interactionsEXP 6480464CTDDrugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA]; NFATC2 protein affects the reaction [bisphenol A results in decreased expression of IL4 mRNA]PMID:19415476 PMID:31714645
IL4affects expressionISOIl4 (Mus musculus)6480464CTDbisphenol A affects the expression of IL4 mRNAPMID:29248573
IL4decreases expressionISOIl4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of IL4 mRNA; bisphenol A results in decreased expression of IL4 proteinPMID:12510852 PMID:29161229 PMID:32156529
IL4decreases expressionISOIl4 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of IL4 mRNAPMID:25181051
IL4increases expressionISOIl4 (Mus musculus)6480464CTDbisphenol A results in increased expression of IL4 mRNA; bisphenol A results in increased expression of IL4 proteinPMID:12709020 PMID:20553123 PMID:29737898 PMID:35278557
IL4increases secretionISOIl4 (Mus musculus)6480464CTDbisphenol A results in increased secretion of IL4 proteinPMID:12711627
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; [bisphenol A affects the susceptibility to Ovalbumin] which results in increased expression of IL4 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in decreased expression of IL4 mRNA; [bisphenol A co-treated with Ovalbumin] results in increased expression of IL4 mRNA; [bisphenol A results in increased susceptibility to Ovalbumin] which results in increased expression of IL4 mRNA; [Ovalbumin co-treated with bisphenol A] results in increased expression of and results in increased secretion of IL4 protein; [Ovalbumin co-treated with bisphenol A] results in increased secretion of IL4 protein; bisphenol A inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]]; bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]; bisphenol A promotes the reaction [Ovalbumin results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; Nitrendipine inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Phytochemicals inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA]; Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Thapsigargin inhibits the reaction [bisphenol A results in increased expression of IL4 protein]PMID:12709020 PMID:20553123 PMID:29737898 PMID:29846729 PMID:31788436 PMID:32012983 PMID:32964057 PMID:35533451 PMID:35739755
IL4multiple interactionsISOIl4 (Rattus norvegicus)6480464CTD[Phytochemicals co-treated with bisphenol A] results in decreased expression of IL4PMID:20136622
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