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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of GPX4 protein

PMID:25772901
affects expressionISORGD:692266480464CTDbisphenol A affects the expression of GPX4 mRNA

PMID:30903817
affects expressionISORGD:7360496480464CTDbisphenol A affects the expression of GPX4 mRNA

PMID:30903817
increases expressionISORGD:692266480464CTDbisphenol A results in increased expression of GPX4 mRNA

PMID:25181051
multiple interactionsISORGD:692266480464CTD[bisphenol A co-treated with Testosterone] results in increased expression of GPX4 mRNA

PMID:26496021
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.