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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736011
Species: Homo sapiens
RGD Object: Gene
Symbol: G6PC1
Name: glucose-6-phosphatase catalytic subunit 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6PC1affects expressionEXP 6480464CTDbisphenol A affects the expression of G6PC1 mRNAPMID:30903817
G6PC1affects expressionISOG6pc1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of G6PC1 mRNAPMID:30903817
G6PC1decreases expressionISOG6pc1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of G6PC1 mRNAPMID:25181051 PMID:32145629
G6PC1increases expressionISOG6pc1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of G6PC1 proteinPMID:37570835
G6PC1increases expressionISOG6pc1 (Mus musculus)6480464CTDbisphenol A results in increased expression of G6PC1 mRNA; bisphenol A results in increased expression of G6PC1 proteinPMID:21932408 PMID:28476547 PMID:30245210
G6PC1multiple interactionsISOG6pc1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Dietary Fats] results in increased expression of G6PC1 protein; [bisphenol A co-treated with tributyltin] results in increased expression of G6PC1 mRNA; bisphenol A promotes the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]; Resveratrol inhibits the reaction [bisphenol A results in increased expression of G6PC1 protein]PMID:25112833 PMID:31129395 PMID:37570835
G6PC1multiple interactionsISOG6pc1 (Mus musculus)6480464CTDbisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC1 mRNA]; bisphenol A inhibits the reaction [Estradiol results in increased expression of G6PC1 protein]; bisphenol A promotes the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]PMID:28476547 PMID:33265944
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