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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735859
Species: Homo sapiens
RGD Object: Gene
Symbol: CACNB3
Name: calcium voltage-gated channel auxiliary subunit beta 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CACNB3increases expressionEXP 6480464CTDbisphenol A results in increased expression of CACNB3 mRNAPMID:29275510
CACNB3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of CACNB3 gene; bisphenol A promotes the reaction [Estradiol results in decreased activity of [CACNA1E protein binds to CACNB3 protein]]; bisphenol A results in decreased activity of [CACNA1E protein binds to CACNB3 protein]; Estradiol promotes the reaction [bisphenol A results in decreased activity of [CACNA1E protein binds to CACNB3 protein]]PMID:23197648 PMID:31601247
CACNB3increases expressionISOCacnb3 (Mus musculus)6480464CTDbisphenol A results in increased expression of CACNB3 mRNAPMID:32156529
CACNB3increases expressionISOCacnb3 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CACNB3 mRNAPMID:25181051
CACNB3multiple interactionsISOCacnb3 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNB3 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNB3 mRNAPMID:25607892
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